Date: Thursday 12 March 2015
Time: 16:00 - 17:30
Location / Room: Les Bans

Organiser:
Jo De Boeck, IMEC, BE

Chair:
Pablo Laguna, CIBER-BBN, ES

Co-Chair:
Josep Maria Haro, Parc Sanitari Sant Joan de Deu, ES

Taking well-known biomarkers of mental disorders together with some other indicators from physiological signals, a multiparametric marker can be elaborated from these constellations of individual data. This session will highlight the relevance of this kind of disorders, the proposed approach and where future opportunities lie for the broad DATE community.

Time	Label	Presentation Title Authors
16:00	12.7.1	TOWARDS A QUANTITATIVE MEASUREMENT OF MENTAL DISORDERS Speaker: Jordi Aguiló, CIBER-BBN, Centro Nacional de Microelectrónica, Universitat Autònoma de Barcelona, ES Abstract The population of Europe is aging at an unprecedented speed as the result of declining reproduction rates and increasing life expectancy. Today, chronic diseases are the main cause of illness in old age but mental disorders such as dementia and late-life depression play also a significant role as well as epilepsy and Alzheimer. Besides, because of the constant pressure the modern way of life imposes on the individuals, stress is also dramatically growing-up to point that the World Health Organization called it a World Wide Epidemic. In particular, the number of patients with dementia is expected to rise sharply as the prevalence of dementia doubles every 5.2 years exponentially between 65 and 85 years of age [3]. Late-life depression is also an important public health problem. Estimated 1-year prevalence rates for depression range from 3% to 10% [6]. For dementia, prevalence rates are estimated between 0.6% and 3.7% for 65 to 69 year olds and 25.2% to 75% for adults 90 years old or older. Additionally, multiple studies have shown high comorbidity between mental disorders and chronic physical illnesses in the elderly. Positive feedback has also been demonstrated between different diseases such as diabetes mellitus, cancer and cardiovascular disease and the occurrence of depression in the elderly. And vice-versa, in older populations there is also a positive feedback between depression and hypertension, diabetes and cardiovascular illnesses. Although the relationship between some biomarkers and mental or acute physical disorders has been known for a long time, due to the complexity of etiology of mental disorders none of them have been considered as gold standard reference. Recently, novel indicators such as the heart rate variability, respiratory abnormalities, neuropeptide Y (NPY) as well as inflammation biomarkers such as interleukin-6 or TNF-a has been proposed. In parallel, computing power has dramatically increased whilst technically and economically viable, non-invasive, reliable and efficient sensors are becoming usable. Taking advantage of these advances, multiparametric markers can be elaborated putting together these constellations of symptoms and indicators. These new multiparametric biomarkers will probably allow a quantitative assessment of the severity of mental disorders. In this session, we will review etiology, the most relevant symptoms, the recent results and a summary of the roadmap for mental health research in Europe; the new trends on using electrophysiological signals to evaluate psychophysiological states as well as the contribution of new nanomaterials in the setup of new Micro-Nano-Bio Systems for diagnosis of mental disorders.
16:15	12.7.2	IMPROVING THE MONITORING AND THE UNDERSTANDING OF MENTAL DISORDERS Speakers: Giovanni de Girolamo1 and Josep Maria Haro2 1IRCCS Fatebenefratelli, IT; 2Parc Sanitari Sant Joan de Deu, ES Abstract Classification and diagnosis of mental disorders is nowadays based on a descriptive taxonomy and is still lacking of biological markers. Devices and techniques coming from new technologies will allow real-time assessment of selected neurophysiological patterns will open the way to a new understanding of mental disorders, making possible new strategies on assessment of patients. In this presentation we will critically discuss these developments.
16:40	12.7.3	WORLD ANALYSIS OF NON-INVASIVE CARDIOVASCULAR SIGNALS FOR THE MONITORING OF PSYCHOPHYSIOLOGICAL STATES Speakers: Michele Orini1 and Pablo Laguna2 1Institute of Cardiovascular Science, University College London, GB; 2CIBER-BBN, Abstract The recent advances in biomedical electronics are paving the road to a new paradigm in health care. Stress and some mental disorders are related to the cardiovascular function in such a way that ECG signals can be used to continuously monitoring the psychophysiological state of patients. We review these methodologies within the new context.
17:05	12.7.4	HEALTHCARE IN AN INTEGRATED DIGITAL WORLD Speaker: Arben Merkoçi, Catalan Institution for Research and Advanced Studies (ICREA) and Institut Català de Nanociència i Nanotecnologia (ICN2), ES Abstract Example designs of nanomaterials-based biosystems related to various clinical biomarkers including neurodegenerative disease will be shown. The developed devices and strategies are intended to be of low cost while offering high analytical performance in screening diagnostic scenarios.
17:30		End of session